PRODUCTION OF GASTRIN

Gastrin is produced by the G-cells of the gastric antrum and to a lesser extent, the duodenum.Two major (and several minor) forms are found in the gastrin-producing tissues and in the circulation, 'big' gastrin (half-life -40 min) and 'little' gastrin (G17, half-life -8 min). Both forms stimulate the secretion of gastric acid and increase gastric antral motility. Excessive amounts are secreted by gastrinomas and are responsible for the Zollinger- Ellison syndrome.