Folates are a naturally occurring group of substances, found in green vegetables and meat, that are structural derivatives of the parent compound folic acid (pteroylglutamic acid).
The different folate compounds are involved in the transfer of one-carbon groups, primarily as methyl or formyl moieties; hence their importance in metabolic pathways involving one-carbon transfers such as the synthesis of methionine, purines, and thymidylate monophosphate (component of DNA).
The characteristic clinical presentation of folates deficiency is megaloblastic anaemia. The causes are manifold including malabsorption, dietary deficiency, and increased requirements (growth, pregnancy, lactation).
The different folate compounds are involved in the transfer of one-carbon groups, primarily as methyl or formyl moieties; hence their importance in metabolic pathways involving one-carbon transfers such as the synthesis of methionine, purines, and thymidylate monophosphate (component of DNA).
The characteristic clinical presentation of folates deficiency is megaloblastic anaemia. The causes are manifold including malabsorption, dietary deficiency, and increased requirements (growth, pregnancy, lactation).
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